10B enriched BSH molecule, NMR and BNCT


Our Work



G1 Group - Departement of Physics -La Sapienza University of Rome
coordinated by Prof. B.Maraviglia



Currently work on 10B and BSH is treated by: Doct. S.Capuani, Doct. R.Campanella and Doct. F.Fasano.

You can find references on our publications in the bibliography page.
We present here our in-progress work. Its purpose is the performance of an in-vivo image of BSH distribution. We have already obtained an image ( first result, september 1998 ) of spatial distribution of 10B enriched BSH at 0,5 mMol concentration in H2O. The BSH was boron 10 enriched at 95%. For this purpose we have used a self-made double resonance probe consisting in an inner saddle and in an outer alderman & grant resonator. They were used to apply pulses on 10B nucleus and on Idrogen nucleus respectively. The experiment was performed in a 7 Tesla static magnetic field, at resonance frequencies of 32MHz for the boron 10 and 300MHz for the idrogen nucleus.
Recently we have obteined ( second result, may 1999 ) an image of the distribution of BSH at low concenmtrations in rabbit blood. This second image give us the information that our technique can work on BSH dissolved in blood too, and not only in water. Blood is a more viscous liquid than water, and viscosity could have negative effects on magnetic interactions between Idrogen and 10B nucleus in BSH. In this case we use a different probe, constituited by an alderman & grant (used on Idrogen nucleus) and a solenoid (used on 10B nucleus).



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silvia.capuani@roma1.infn.it - fabrizio.fasano@roma1.infn.it